Clinical Calorie Restriction Mimetics™

The restriction of calorie intake has been shown to exert powerful anti-aging benefits in several animal species; and it may be effective in humans. The act of substantial and continuous calorie restriction (at least 30% reduction) is a monumental task for many individuals, with obvious problems of compliance. There are several proposed or documented effects of calorie restriction on body structures and functions, including: insulin sensitization, apoptosis regulation, decreased oxidative stress, stimulation of endogenous growth factors, enhanced tissue repair, anti-stress actions and modulation of protein metabolism. Experimental calorie restriction often improves protein metabolism by the variable elimination of cross-linked protein products (AGEs), as a consequence of down regulation of "chaperone molecules", with resulting increase in hepatic protein elimination. Calorie restriction has been associated with reductions in total blood cholesterol and blood markers of inflammation; it causes improvements in glucose tolerance (anti-diabetic effect).

These beneficial effects of calorie restriction have been observed most often in animal experiments (including primates), and they are the subject of contemporary research in humans. While many of these benefits of calorie restriction are related to reduction of adipose tissue mass, other complex factors operate. The concept of "calorie restriction mimetics" was proposed in the late 1990s and this resulted in several basic science experiments that have demonstrated the effects of calorie restriction in animals on promoting substantial extensions of lifespan in animals by effects on gene pathways. Several drugs, nutrients or botanicals have been proposed as agents that can mimic the effects of calorie restriction, in a variable manner.

A number of examples of calorie restriction mimetics have variable beneficial effects on glucose metabolism and they can modulate genes that are involved in mechanisms of aging, e.g. resveratrol and apoptosis regulation, the oxidized form of nicotinamide adenine dinucleotide in the activation of Sir2p and the restoration of gene activity (daf-2 and age-1) in nerve cells. Well-defined examples of calorie-restriction mimetics include: resveratrol, gymnema alkaloids, alpha lipoic acid, cinnamon (methylhydroxychalones), indoacetate, oxaloacetate, metformin and thiazolidinediones.

While calorie restriction mimetics may appear to focus on the issue of calorie restriction per se, it is clear that these agents match the potential correction of several hypotheses of aging (e.g. theories of free radical damage, protein cross linking, repair budgets, anti-inflammatory approaches, dysglycemia etc). In brief, calorie restriction mimetic factors are a unique class of agents that are biological response modifiers. The synergistic use of calorie restriction mimetic factors is a logical approach to attempt to retard tissue aging, and it has an evidence-based perspective. While it is naive to think that there is a "magic bullet" approach to anti-aging2, the adjunctive use of remedies of natural origin as recuperative or anti-aging factors has an established basis in good scientific agreement.

PRODUCT SUMMARY: CALORIE RESTRICTION MIMETICS™ Calorie Restriction Mimetics™contains a proprietary blend of substances that are classified in this new group of potential agents that may alter body structures and functions associated with aging. The formulation of Calorie Restriction Mimetics™contains: Resveratrol (50% extract), L-Carnosine, Gymnema sylvestre (25% extract of gymnemosides), alpha lipoic aicd, cinnamon bark (15% extract as a source of methylhydroxychalones), N-Acetyl-L-Carnitine, grape seed extract (95% oligomeric proanthocyanidins, Vitis vinifera), ellagic acid (40% extract of pomegranate fruit, Punica granatum) green tea extract (95% polyphenols, Camellia sinensis), pine bark (85% extract, Pinus maritime), and avocado fruit (Persea Americana).